The Journal of Proteolysis provides an international forum for the electronic publication of the whole spectrum of high-quality articles and reviews in all areas of proteolysis and proteolytic pathways.

The Journal of Proteolysis is committed to rigorous yet rapid reviewing. Final versions are published electronically immediately upon acceptance.

ISSN: 2331-6977

Breast Cancer Awareness Month 2014 - Journal of Proteolysis Support

Authors get FREE publication for submissions directly related to research for the cure for breast cancer and 25% off publication fees for manuscripts on all other topics submitted through the end of October 2014.

Journal of Proteolysis pledges to donate $100 to Research for the Cure per each cancer research related submission and $50 for all other published October 2014 submissions.

Thereby, Authors are provided with another opportunity to be part of BCAM movement by submitting their manuscripts through the end of October 2014.
Excellent tool for prediction of the potential cleavage sites for MMPs

Scientists of Sanford Burnham Medical Research Institute (La Jolla, CA, USA) recently announced the opening of a new web server providing excellent tool for prediction of the potential cleavage sites for matrix metalloproteinases (MMPs).

The server is capable to predict cleavage positions for 11 human MMPs: MMP-2, -3, -8, -9, -10, -14, -15, -16, -17, -24, -25, for which statistical profiles have been derived based on high throughput phage display experiments. The server accepts the structure data (in PDB format), the sequence data (in FASTA format) or UNIPROT id of putative protein target as an input and produces information about the position of tentative cleavage sites.

The server additionally provides other available information for your input protein:

  • Co-localization and co-expression of the input protein and its processing MMP
  • Positions of post-translational modifications (PTMs), and Single Nucleotide Polymorphism data (SNPs) that could interfere with the cleavage event (the information about the disease related SNPs is also provided if available)
  • Signal peptide and secondary structure, solvent exposure and transmembrane domain(s)
  • VMS - virtual mass spectroscopy (the server produces ordered mass spectrum of expected mass fragments based on the position of tentative cleavage position, which would be very helpful in interpreting experimental MS data).
  • Server matches the structure to your input protein sequence and displays potential cleavage sites, PTMs and SNPs mapped on this structure.

For more information please visit: But, if you have any specific questions or need more information, you can directly contact Dr. Piotr Cieplak by e-mail:


Call For PapersThe Journal of Proteolysis cordially invites researchers and principal investigators to submit high-quality, innovative and original research papers related to the field of proteolysis and proteolytic pathways. Submissions are accepted in the form of original papers, short communications and reviews.

Why publish in the Journal of Proteolysis?

  • Journal of Proteolysis provides a unique opportunity to publish novel insights and original works in the area of proteolysis and proteolytic pathways in highly specialized academic journal.
  • Open Access publishing option. All articles will be free to download for readers worldwide.
  • Low publication fee. Publication fees for regular research papers and short communications are minimal and one of the lowest in the row of bio-med oriented academic journals.
  • User-friendly electronic submission system. For manuscript submission guidelines please visit the guidelines for authors section on Information for Authors.
  • High-quality yet rapid peer review. The result of peer review for submitted papers will be provided approximately within one month after initial submission.
  • Fast Publication of accepted manuscripts. As soon as the final version of accepted paper is ready, it will immediately appear on the journal website and will be accessible for download.

We look forward to receiving your manuscripts

Journal of Proteolysis Editorial Office
Opening Issue

The Journal of Proteolysis is the open-access online-only journal. It announces the launch of its first issue at the beginning of 2014 and welcomes the original papers and high-quality contributions across the multidisciplinary scientific research of the entire spectrum of proteolysis, proteolytic events and pathways.


The Journal of Proteolysis topics:

  • Proteolytic pathways in cellular regulations
  • Post-translational proteolytic processing and protein degradation
  • Proteolytic events in diseases and proteomics studies
  • Characterization of viral, microbial, plant and mammalian proteinases
  • Proteinases in host-pathogen interactions
  • Natural proteinase inhibitors
  • Drug design studies of proteinases inhibitors
  • Proteinases and their inhibitors in medicine and medical applications
  • Tools, new methods and laboratory applications for scientific research in the area of proteolytic events and proteinases.
Vol 1, No 1 (2014)
Proteolysis and Proteolytic Pathways – Life After the Point of No Return 1-2
Proteolysis is the irreversible post-translational modification affecting a specific peptide bond in a target protein substrate.
Proteolysis Vol 1, No 1 (2014); doi:10.13176/14.609